Innate Immunity to Intracellular Pathogens: Balancing Microbial Elimination and Inflammation
نویسندگان
چکیده
منابع مشابه
Micro-balancing innate immunity to Salmonella.
MicroRNAs are 19–24 nt-long RNAs that post-transcriptionally regulate eukaryotic gene expression. Beside their important roles in patterning and development, miRNAs also orchestrate responses to pathogen infections. In this issue of The EMBO Journal, Schulte et al (2011) investigate the miRNA response of mammalian cells to the intracellular bacterium Salmonella. They find that Salmonella trigge...
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A multicellular organism is subject to constant microbial exposure throughout its life. These interactions can be transient or permanent, with microbes ranging from those considered commensal to pathogenic [1]. The initial host response to these myriad microbes relies upon the innate immune system. This highly conserved and ancient arm of host defense has generally been thought of as hardwired ...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2017
ISSN: 1931-3128
DOI: 10.1016/j.chom.2017.07.005